NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)

STTR · Phase: BOTH · Topic PA-27-102 · Solicitation PA-27-102

Background The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (also known as America's Seed Fund) are major sources of early-stage funding for U.S. technology development and commercialization. By providing awards to SBCs that partner with non-profit research institutions, the STTR program supports the commercialization of innovative technologies and strengthens both U.S. small businesses and research communities. The National Institutes of Health (NIH) uses these programs to help US-owned and operated small businesses develop promising technologies and products that support the NIH mission to enhance health, lengthen life, and reduce illness and disability. NIH is required to set aside 0.45% of its extramural research budget for the STTR program. What this NOFO supports This NOFO supports a small business to do the research and development (R&D) needed to develop a commercial product in partnership with a non-profit research institution. STTR projects are required to have a formal collaboration with a nonprofit research institution, such as a university. The Program Director/Principal investigator (PD/PI) may be employed with either the small business or the partnering nonprofit research institution. Regardless of the PD/PI employment, the award is always made to the small business. See eligibility requirements in Section III. For projects that do not depend on such a collaboration, a small business can apply to SBIR NOFO PA-27-100. Applicants are strongly encouraged to contact program staff prior to applying to help choose the best funding opportunity for their project. The STTR Program supports projects through multiple phases: Phase I: Establish the technical merit and feasibility of the proposed R&D. Phase II: Continue R&D to advance toward commercialization. After Phase II, NIH expects small business concerns (SBCs) to fully commercialize the product or technology using non-SBIR/STTR funds (federal or non-federal). This NOFO accepts STTR Phase I, Phase II, Direct to Phase II (NIH only), and Fast-Track (NIH-only), grant applications from eligible United States SBCs. NIH Fast-Track: The NIH Fast-Track allows both Phase I and Phase II of a project to be submitted and reviewed together as one application to reduce or eliminate the funding gap between phases. NIH Direct to Phase II: Small businesses that have already demonstrated scientific and technical merit and feasibility but have not received a Phase I SBIR or STTR for that project, can apply for a Direct to Phase II award. The NIH will accept Direct to Phase II applications regardless of the funding source for the work on which the proposed Phase II research is based. Direct to Phase II awards should be submitted as "New" applications and not continuations ("Renewal") of Phase I SBIR or STTR projects. Small businesses that are eligible to submit a Phase II application for a project that was supported with a Phase I SBIR or STTR award are expected to submit the regular Phase II application as a "Renewal" of the awarded Phase I SBIR or STTR project. Only one Phase II application may be awarded for a specific project supported by a Phase I award. Phase IIB Strategic Breakthrough grant applications should be submitted to PA-27-101 (SBIR). Scientific and Technical Scope STTR applications should propose a feasibility and/or R&D study that contributes to the missions of any NIH,CDC or FDA components participating in this NOFO. See NIH Institutes, Centers, and Offices and Small Business Funding Considerations and Contacts for Institute, Center, and Office (ICO) specific missions, interest areas, funding priorities, and funding considerations. Staff within the NIH's Center for Scientific Review (CSR) office, the single receiving point for all NIH grant applications, will assign all applications to the most appropriate participating component. Applicants are not required to identify a potential awarding component prior to submiss…

SBIR/STTR 은 미국 중소기업만 지원할 수 있습니다(Small Business Act 법정 요건). • 계열사를 포함해 상시 종업원 500명 이하 • 미국 시민 또는 영주권자 1인 이상이 50%를 초과해 직접 소유·지배 • 미국 내 사업장을 두고 주로 미국 내에서 사업을 영위할 것 • 수행책임자(PI)의 주된 근무처가 신청 기업일 것 출처: https://www.sbir.gov/faq/eligibility-requirements

Primary country

🇺🇸 United States

Also eligible

None

Foreign companies

No

Local entity

Required

Location condition

미국 내 사업장을 두고 미국 시민·영주권자가 50%를 초과해 소유한 중소기업만 신청할 수 있습니다(법정 요건).

Document requirements were not captured (needs verification). Check the official announcement.

Application process not captured.

Evaluation process not captured.

Process steps were not captured.

Generated by local:rules-v1 · 4h ago

The announcement does not say what has to be submitted, so the disclosure exposure cannot be judged. the scope of the material requested is not stated. The awarding body is U.S. Department of Health and Human Services. 8 fields could not be read and must be checked in the announcement and the grant agreement.

This assessment is derived from the stored announcement, document and contract fields. Anything the source does not state is marked "needs verification" — it never asserts that your idea will be taken. Generated by local:rules-v1 · 4h ago

Official URL

https://simpler.grants.gov/opportunity/ee37f2de-b959-4b45-86a9-43d06c944f24

Application URL

https://simpler.grants.gov/opportunity/ee37f2de-b959-4b45-86a9-43d06c944f24

Last fetched

2026.08.20

Human review

Not reviewed — check the official announcement

First seen

2026.08.20

Data status

Auto-collected, not reviewed

AI enrichment

local:rules-v1 · 4h ago